I explain you quickly what I'm doing.
I substituted the "Eredivisie" by the Brasilian League.
I substituted the "Group A" teams by south american teams. In these teams there are 11 argentinan teams and 2 Chilian teams (Colo Colo and Univesiada Catolica). The last 6 teams we'll probably be 2 Mexicans, 2 from Uruguay and 2 Colombians.
I put Celtic and Rangers in the First League instead of 2 English teams.
I put Porto and Benfica in the Spanish League instead of 2 Spanish teams.
I put Ajax, PSV and Feyenoord in the Bundesliga instead of 3 German teams.
I'm going to put Fenerbahce and Galatassaray in the Italian League instead of 2 Italian teams.
I put CSKA Moscou, Olympiakos and Panathinaikos in the "Group B" teams.
Perhaps i'll make some others changes. These changes could be to put CSKA Moscou, Olympiakos and Panathinaikos in the French League instead of 3 french teams. And there will have 3 others south american teams.
If i can help you, ask me and we'll see.

P.S.: My Option File is the Superpatch 2.0